G-quadruplex DNA/protoporphyrin IX-based synergistic platform for targeted photodynamic cancer therapy.

Abstract

Photodynamic therapy (PDT) is an emerging technique to induce cancer cell death. However, the tumor specificity, cellular uptake and biodistribution of many photosensitizers urgently need to be improved. In this regard, we show here that the integrated nanoassemblies based on G-quadruplex DNAs (GQDs)/protoporphyrin IX (PPIX) can serve as a synergistic… (More)
DOI: 10.1016/j.talanta.2014.11.039

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