G-proteins modulate cumulative inactivation of N-type (Cav2.2) calcium channels.

@article{McDavid2006GproteinsMC,
  title={G-proteins modulate cumulative inactivation of N-type (Cav2.2) calcium channels.},
  author={Sarah M McDavid and Kevin P. M. Currie},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 51},
  pages={
          13373-83
        }
}
Precise regulation of N-type (Ca(V)2.2) voltage-gated calcium channels (Ca-channels) controls many cellular functions including neurotransmitter and hormone release. One important mechanism that inhibits Ca2+ entry involves binding of G-protein betagamma subunits (Gbetagamma) to the Ca-channels. This shifts the Ca-channels from "willing" to "reluctant" gating states and slows activation. Voltage-dependent reversal of the inhibition (facilitation) is thought to reflect transient dissociation of… CONTINUE READING

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