G proteins mediate changes in cell shape by stabilizing the axis of polarity.

@article{Nern2000GPM,
  title={G proteins mediate changes in cell shape by stabilizing the axis of polarity.},
  author={Aljoscha Nern and Robert A Arkowitz},
  journal={Molecular cell},
  year={2000},
  volume={5 5},
  pages={853-64}
}
Upon exposure to mating pheromone, yeast cells change their form to pear-shaped shmoos. We looked at pheromone-dependent cell shape changes in mutants that are unable to orient growth during mating and unable to choose a bud site. In these double mutants, cell surface growth, secretion sites, cytoskeleton, and pheromone receptors are spread out, explaining why these cells are round. In contrast, polarity establishment proteins localize to discrete sites in these mutants. However, the location… CONTINUE READING

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