G proteins in cancer: the prostate cancer paradigm.

  title={G proteins in cancer: the prostate cancer paradigm.},
  author={Yehia Daaka},
  journal={Science's STKE : signal transduction knowledge environment},
  volume={2004 216},
  • Yehia Daaka
  • Published 2004 in
    Science's STKE : signal transduction knowledge…
Signal transduction research investigating mechanisms of androgen-independent prostate cancer cell proliferation has historically focused on the role of androgen and peptide growth factor receptors. More recent work has raised the idea that intracellular signaling mechanisms triggered by extracellular hormonal factors acting through heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can also mediate and sustain this pathologic process. Prostate cancer… CONTINUE READING
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