G proteins as biological targets for anti-allergic drugs?

  title={G proteins as biological targets for anti-allergic drugs?},
  author={J. P. Rihoux and Jo{\"e}lle Masliah and Gilbert Béréziat and Wolfgang Koenig},
  journal={International archives of allergy and immunology},
  volume={113 1-3},
  • J. P. Rihoux, Joëlle Masliah, +1 author Wolfgang Koenig
  • Published 1997
  • Medicine, Biology
  • International archives of allergy and immunology
  • The inhibiting effect of the H1 antihistamine cetirizine on the release of mediators (LTB4, arachidonic acid and phospholipase A2) was measured in different cells in vitro (human PMN, deltaF508 cells, chinese hamster ovary cells and rabbit chondrocytes) using different agonists (fMLP, NaF, calcium ionophore A 23187, bradykinin, adrenaline and IL-1). It was shown that physiological concentrations of the drug inhibited the release when activation of receptor-coupled G proteins was involved. By… CONTINUE READING