G proteins are involved in the suppression of collagen alpha 1 (I) gene expression in cultured rat hepatic stellate cells.

@article{SolsHerruzo1998GPA,
  title={G proteins are involved in the suppression of collagen alpha 1 (I) gene expression in cultured rat hepatic stellate cells.},
  author={Jos{\'e} Antonio Sol{\'i}s-Herruzo and Inmaculada Hern{\'a}ndez and Paz de la Torre and Itxaso Garc{\'i}a and Josep Anton S{\'a}nchez and Inmaculada Fern{\'a}ndez and Giancarlo Castellano and Teresa Muņoz-Yag{\"u}e},
  journal={Cellular signalling},
  year={1998},
  volume={10 3},
  pages={173-83}
}
We analyse the role of the G proteins in regulating collagen gene expression by measuring collagen alpha 1(I) mRNA levels in cultured hepatic stellate cells in basal conditions and after stimulating or inhibiting the major intracellular signalling pathways. Stimulation of Gs protein and adenylyl cyclase or the addition of 8Br-cAMP to the cells led to a decrease in collagen alpha 1(I) mRNA levels, while blocking protein kinase A abolished this effect. Blocking Gi protein, phospholipase A2 and C… CONTINUE READING

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