G proteins: more than transducers of receptor-generated signals?

  title={G proteins: more than transducers of receptor-generated signals?},
  author={Stefan Engelhardt and Francesca Rochais},
  journal={Circulation research},
  volume={100 8},
Signaling through the activation of G proteins represents the most widely used signaling pathway in mammalian biology.1,2 Classically, a transmembrane receptor comprising seven transmembrane domains (G protein-coupled receptor, GPCR) is activated by an extracellular stimulus and transduces this information to heterotrimeric G proteins through a conformational change of the receptor protein. Throughout evolution, a large variety of GPCRs has evolved to detect a wide spectrum of signals ranging… CONTINUE READING


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