G protein specificity: traffic direction required.

  title={G protein specificity: traffic direction required.},
  author={Paul R Albert and Liliane Robillard},
  journal={Cellular signalling},
  volume={14 5},
This review focuses on the coupling specificity of the Galpha and Gbetagamma subunits of pertussis toxin (PTX)-sensitive G(i/o) proteins that mediate diverse signaling pathways, including regulation of ion channels and other effectors. Several lines of evidence indicate that specific combinations of G protein alpha, beta and gamma subunits are required for different receptors or receptor-effector networks, and that a higher degree of specificity for Galpha and Gbetagamma is observed in intact… CONTINUE READING
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