G protein modulation of voltage-gated calcium channels.

  title={G protein modulation of voltage-gated calcium channels.},
  author={Annette C Dolphin},
  journal={Pharmacological reviews},
  volume={55 4},
Calcium influx into any cell requires fine tuning to guarantee the correct balance between activation of calcium-dependent processes, such as muscle contraction and neurotransmitter release, and calcium-induced cell damage. G protein-coupled receptors play a critical role in negative feedback to modulate the activity of the CaV2 subfamily of the voltage-dependent calcium channels, which are largely situated on neuronal and neuro-endocrine cells. The basis for the specificity of the… CONTINUE READING
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