G protein modulation of K2P potassium channel TASK-2

  title={G protein modulation of K2P potassium channel TASK-2},
  author={Carolina C A{\~n}azco and Gaspar Pe{\~n}a-M{\"u}nzenmayer and Carla Araya and L. Pablo Cid and Francisco V Sep{\'u}lveda and Mar{\'i}a Isabel Niemeyer},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
TASK-2 (K2P5.1) is a background K+ channel opened by extra- or intracellular alkalinisation that plays a role in renal bicarbonate handling, central chemoreception and cell volume regulation. Here, we present results that suggest that TASK-2 is also modulated by Gβγ subunits of heterotrimeric G protein. TASK-2 was strongly inhibited when GTP-γ-S was used as a replacement for intracellular GTP. No inhibition was present using GDP-β-S instead. Purified Gβγ introduced intracellularly also… CONTINUE READING


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