G protein modulation of K2P potassium channel TASK-2

@article{Aazco2013GPM,
  title={G protein modulation of K2P potassium channel TASK-2},
  author={Carolina C A{\~n}azco and Gaspar Pe{\~n}a-M{\"u}nzenmayer and Carla Araya and L. Pablo Cid and Francisco V Sep{\'u}lveda and Mar{\'i}a Isabel Niemeyer},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2013},
  volume={465},
  pages={1715-1726}
}
TASK-2 (K2P5.1) is a background K+ channel opened by extra- or intracellular alkalinisation that plays a role in renal bicarbonate handling, central chemoreception and cell volume regulation. Here, we present results that suggest that TASK-2 is also modulated by Gβγ subunits of heterotrimeric G protein. TASK-2 was strongly inhibited when GTP-γ-S was used as a replacement for intracellular GTP. No inhibition was present using GDP-β-S instead. Purified Gβγ introduced intracellularly also… CONTINUE READING

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Potassium channels: structures, diseases, and modulators.

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References

Publications referenced by this paper.
Showing 1-10 of 69 references

The pore structure and gating mechanism of K2P channels

The EMBO journal • 2011
View 4 Excerpts
Highly Influenced

Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 3 Excerpts
Highly Influenced

TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation

DH Woo, KS Han, +9 authors CJ Lee
Cell • 2012
View 1 Excerpt

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