G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes.

Abstract

To evaluate the effects of liothyronine (3,5,3'-triiodo-L-thyronine, T(3)) on Na(+) channel current (I(Na)) properties, I(Na) was recorded in adult guinea pig ventricular myocytes. T(3) (1 nM) acutely increased whole cell I(Na) and shifted the steady-state I(Na) inactivation curve dose dependently. When the pipette solution contained 100 microM GTP or… (More)

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@article{Sen2002GPM, title={G protein modulates thyroid hormone-induced Na(+) channel activation in ventricular myocytes.}, author={Luyi Sen and Yoshihide Sakaguchi and Guanggen Cui}, journal={American journal of physiology. Heart and circulatory physiology}, year={2002}, volume={283 5}, pages={H2119-29} }