G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics.

@article{Kohlrausch2008GproteinG8,
  title={G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics.},
  author={Fabiana Barzotti Kohlrausch and Ang{\'e}lica Salatino-Oliveira and Clarissa Severino Gama and Maria In{\^e}s Rodrigues Lobato and Paulo da Silva Belmonte-de-Abreu and Mara H Hutz},
  journal={Pharmacogenomics},
  year={2008},
  volume={9 10},
  pages={1429-36}
}
AIMS Clozapine treatment of schizophrenia is effective only in 30-60% of individuals. Since genetic factors are believed to play a significant role in the variation of response to antipsychotics, the aim of the present study was to verify the effect of a G-protein gene polymorphism on clozapine response and clozapine-induced generalized seizures in Brazilian patients with schizophrenia. PATIENTS & METHODS In total, 121 schizophrenic patients in treatment with clozapine were genotyped for the… CONTINUE READING