G protein-dependent activation of mast cell by peptides and basic secretagogues.

@article{Ferry2002GPA,
  title={G protein-dependent activation of mast cell by peptides and basic secretagogues.},
  author={Xavier Ferry and Stephan Brehin and R. Kamel and Yves Landry},
  journal={Peptides},
  year={2002},
  volume={23 8},
  pages={1507-15}
}
Signaling pathways leading to exocytosis and arachidonate release from serosal mast cells by basic secretagogues, including cationic peptides, arise from the involvement of betagamma subunits from G(i2) and G(i3) GTP-binding proteins. The original concept that basic secretagogues directly interact with G proteins implicated the entry of secretagogues into mast cells. This has been demonstrated only for the neuropeptide substance P. Basic secretagogues might share a common mechanism of… CONTINUE READING

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