G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.

@article{Lavine2002GPR,
  title={G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.},
  author={Natalie Lavine and Nathalie Ethier and James N Oak and Lin Pei and Fang Liu and Phan Trieu and Raymond V. Rebois and Michel Bouvier and Terence E. H{\'e}bert and Hubert H M Van Tol},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 48},
  pages={46010-9}
}
A large number of studies have demonstrated co-purification or co-immunoprecipitation of receptors with G proteins. We have begun to look for the presence of effector molecules in these receptor complexes. Co-expression of different channel and receptor permutations in COS-7 and HEK 293 cells in combination with co-immunoprecipitation experiments established that the dopamine D(2) and D(4), and beta(2)-adrenergic receptors (beta(2)-AR) form stable complexes with Kir3 channels. The D(4)/Kir3 and… CONTINUE READING