G-protein-coupled receptors as fat sensors.

@article{Vinolo2012GproteincoupledRA,
  title={G-protein-coupled receptors as fat sensors.},
  author={Marco Antonio R Vinolo and Sandro Massao Hirabara and Renato Curi},
  journal={Current opinion in clinical nutrition and metabolic care},
  year={2012},
  volume={15 2},
  pages={
          112-6
        }
}
PURPOSE OF REVIEW It has been demonstrated that fatty acids (FAs) are physiological ligands of G-protein-coupled receptors (GPRs). Activation of the GPRs (40, 41, 43, 84, 119 and 120) by FAs or synthetic agonists modulates several responses. In this review, we discuss the current knowledge on the actions of FA-activated GPRs and their relevance in normal and pathological conditions. RECENT FINDINGS Studies have shown that FA-activated GPRs modulate hormone secretion (incretin, insulin and… CONTINUE READING
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