G-protein-coupled receptors and cancer

@article{Dorsam2007GproteincoupledRA,
  title={G-protein-coupled receptors and cancer},
  author={Robert T. Dorsam and J. Silvio Gutkind},
  journal={Nature Reviews Cancer},
  year={2007},
  volume={7},
  pages={79-94}
}
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and metastasis. Malignant cells often hijack the normal physiological functions of GPCRs to survive, proliferate autonomously, evade the immune system, increase their blood supply, invade their surrounding tissues and disseminate to other organs. This Review will address our current understanding of the many roles of GPCRs… Expand

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