G-protein-coupled receptors, Hedgehog signaling and primary cilia.

@article{Mukhopadhyay2014GproteincoupledRH,
  title={G-protein-coupled receptors, Hedgehog signaling and primary cilia.},
  author={Saikat Mukhopadhyay and Rajat Rohatgi},
  journal={Seminars in cell & developmental biology},
  year={2014},
  volume={33},
  pages={63-72}
}
The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 37 extracted citations

Hedgehog receptor function during craniofacial development.

Developmental biology • 2016
View 7 Excerpts
Highly Influenced

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…