G-protein-coupled receptors, Hedgehog signaling and primary cilia.

  title={G-protein-coupled receptors, Hedgehog signaling and primary cilia.},
  author={Saikat Mukhopadhyay and Rajat Rohatgi},
  journal={Seminars in cell & developmental biology},
The Hedgehog (Hh) pathway has become an important model to study the cell biology of primary cilia, and reciprocally, the study of ciliary processes provides an opportunity to solve longstanding mysteries in the mechanism of vertebrate Hh signal transduction. The cilium is emerging as an unique compartment for G-protein-coupled receptor (GPCR) signaling in many systems. Two members of the GPCR family, Smoothened and Gpr161, play important roles in the Hh pathway. We review the current… CONTINUE READING
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