G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.

@article{Mcsai2003GproteincoupledRS,
  title={G-protein-coupled receptor signaling in Syk-deficient neutrophils and mast cells.},
  author={Attila M{\'o}csai and Hong Zhang and Zolt{\'a}n Jakus and Jiro Kitaura and Toshiaki Kawakami and Clifford A Lowell},
  journal={Blood},
  year={2003},
  volume={101 10},
  pages={4155-63}
}
The Syk tyrosine kinase is essential for immunoreceptor and multiple integrin functions as well as being implicated in signaling from G-protein-coupled receptors (GPCR) in cell lines, transfection systems, and pharmacologic studies. In contrast, using Syk-deficient primary cells, we show here that Syk does not play a major functional role in chemoattractant/chemokine signaling in neutrophils and mast cells. syk(-/-) neutrophils showed normal respiratory burst and degranulation in response to… CONTINUE READING
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