G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon.

@article{Rey2004GPR,
  title={G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon.},
  author={Osvaldo Rey and Joseph R. Reeve and Elena Zhukova and James Sinnett-Smith and Enrique 4 Rozengurt},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 33},
  pages={34361-72}
}
Protein kinase D (PKD) is a serine/threonine protein kinase activated by G protein-coupled receptor (GPCR) agonists through an incompletely characterized mechanism that includes its reversible plasma membrane translocation and activation loop phosphorylation via a protein kinase C (PKC)-dependent pathway. To gain a better understanding of the mechanism regulating the activation of PKD in response to GPCR stimulation, we investigated the role of its rapid plasma membrane translocation on its… CONTINUE READING

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