G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.

@article{Walker2004GPR,
  title={G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.},
  author={J K L Walker and Raul R. Gainetdinov and David S. Feldman and Peter K. McFawn and Marc G. Caron and Robert J. Lefkowitz and R T Premont and John T. Fisher},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={286 2},
  pages={
          L312-9
        }
}
G protein-coupled receptors (GPCRs) transduce extracellular signals into intracellular events. The waning responsiveness of GPCRs in the face of persistent agonist stimulation, or desensitization, is a necessary event that ensures physiological homeostasis. GPCR kinases (GRKs) are important regulators of GPCR desensitization. GRK5, one member of the GRK family, desensitizes central M(2) muscarinic receptors in mice. We questioned whether GRK5 might also be an important regulator of peripheral… 
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