G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition.

@article{So2012GPR,
  title={G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition.},
  author={Christopher H. So and Allison M. Michal and Rouzbeh Mashayekhi and Jeffrey L. Benovic},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 21},
  pages={17088-99}
}
G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, leading to their desensitization and endocytosis. GRKs have also been implicated in phosphorylating other classes of proteins and can localize in a variety of cellular compartments, including the nucleus. Here, we attempted to identify potential nuclear substrates for GRK5. Our studies reveal that GRK5 is able to interact with and phosphorylate nucleophosmin (NPM1) both in vitro and in intact cells… CONTINUE READING
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GRK5 Phosphorylates Nucleophosmin

  • A. M. Michal, C. H. So, N. Beeharry, H. Shankar, R. Mashayekhi, Yen
  • MAY 18,
  • 2012
Highly Influential
4 Excerpts

G protein - coupled - receptor kinase 5 is localized to centrosomes and regulates cell cycle progression

  • J. L. Benovic
  • J . Biol . Chem .
  • 2012

G protein GRK5 Phosphorylates Nucleophosmin 17098 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

  • J. H. Wu, L. Zhang, +7 authors J FreedmanN.
  • MAY 18,
  • 2012
1 Excerpt

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