G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.

@article{Peppel1997GPR,
  title={G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.},
  author={Karsten C. Peppel and Ingrid Boekhoff and Phillip McDonald and Heinz Breer and Marc G. Caron and Robert J Lefkowitz},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 41},
  pages={25425-8}
}
G protein-coupled receptor kinases (GRKs) 2 and 3 (beta-adrenergic receptor kinases 1 and 2 (betaARK1 and -2)) mediate the agonist-dependent phosphorylation and uncoupling of many G protein-coupled receptors. These two members of the GRK family share a high degree of sequence homology and show overlapping patterns of substrate specificity in vitro. To define their physiological roles in vivo we have generated mice that carry targeted disruption of these genes. In contrast to GRK2-deficient mice… CONTINUE READING

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