G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms.

@article{Santulli2013GproteincoupledRK,
  title={G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms.},
  author={Gaetano Santulli and Bruno Trimarco and Guido Iaccarino},
  journal={High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension},
  year={2013},
  volume={20 1},
  pages={5-12}
}
Numerous factors partake in the fine-tuning of arterial blood pressure. The heptahelical G-protein-coupled receptors (GPCRs) represent one of the largest classes of cell-surface receptors. Further, ligands directed at GPCRs account for nearly 30 % of current clinical pharmaceutical agents available. Given the wide variety of GPCRs involved in blood pressure control, it is reasonable to speculate for a potential role of established intermediaries involved in the GPCR desensitization process… CONTINUE READING