G-protein coupled receptor kinase (GRK)-5 regulates proliferation of glioblastoma-derived stem cells.

@article{Kaur2013GproteinCR,
  title={G-protein coupled receptor kinase (GRK)-5 regulates proliferation of glioblastoma-derived stem cells.},
  author={Gurvinder Kaur and Joseph M. Kim and Rajwant Kaur and Ili Tan and Orin G. Bloch and Matthew Sun and Michael M Safaee and Michael C. Oh and Michael E. Sughrue and Joanna J Phillips and Andrew T. Parsa},
  journal={Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia},
  year={2013},
  volume={20 7},
  pages={1014-8}
}
Glioblastoma multiforme (GBM) is a grade IV malignant brain tumor with high mortality and has been well known to involve many molecular pathways, including G-protein coupled receptor (GPCR)-mediated signaling (such as epithelial growth factor receptor [EGFR] and platelet derived growth factor receptor [PDGFR]). G protein-coupled receptor kinases (GRK) directly regulate GPCR activity by phosphorylating activated agonist-bound receptors to desensitize signaling and internalize receptors through… CONTINUE READING
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