G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.

@article{Hawkins2007GPR,
  title={G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence.},
  author={Brian J. Hawkins and Laura A Solt and Ibrul Chowdhury and Altaf S. Kazi and Md. Ruhul Abid and William C. Aird and Michael W. May and J. Kevin Foskett and Muniswamy Madesh},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 21},
  pages={
          7582-93
        }
}
Receptor-mediated signaling is commonly associated with multiple functions, including the production of reactive oxygen species. However, whether mitochondrion-derived superoxide (mROS) contributes directly to physiological signaling is controversial. Here we demonstrate a previously unknown mechanism in which physiologic Ca(2+)-evoked mROS production plays a pivotal role in endothelial cell (EC) activation and leukocyte firm adhesion. G protein-coupled receptor (GPCR) and tyrosine kinase… CONTINUE READING
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