G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo.

@article{Wu2013GproteinCR,
  title={G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo.},
  author={Melissa P. Wu and Jamie R. Doyle and B Barry and Ariane Beauvais and Anete Rozkalne and Xianhua Piao and Michael W. Lawlor and Alan S. Kopin and Christopher A. Walsh and Emanuela Gussoni},
  journal={The FEBS journal},
  year={2013},
  volume={280 23},
  pages={6097-113}
}
Mammalian muscle cell differentiation is a complex process of multiple steps for which many of the factors involved have not yet been defined. In a screen to identify the regulators of myogenic cell fusion, we found that the gene for G-protein coupled receptor 56 (GPR56) was transiently up-regulated during the early fusion of human myoblasts. Human mutations in the gene for GPR56 cause the disease bilateral frontoparietal polymicrogyria; however, the consequences of receptor dysfunction on… CONTINUE READING
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