G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.

@article{Luo2011GPR,
  title={G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination.},
  author={Rong Luo and S J Jeong and Zhaohui Jin and Natalie Strokes and Shihong Li and Xianhua Piao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 31},
  pages={12925-30}
}
GPR56, an orphan G protein-coupled receptor (GPCR) from the family of adhesion GPCRs, plays an indispensable role in cortical development and lamination. Mutations in the GPR56 gene cause a malformed cerebral cortex in both humans and mice that resembles cobblestone lissencephaly, which is characterized by overmigration of neurons beyond the pial basement membrane. However, the molecular mechanisms through which GPR56 regulates cortical development remain elusive due to the unknown status of… CONTINUE READING
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