G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes.

@article{Choi2014GproteinCR,
  title={G-protein coupled receptor 40 agonists as novel therapeutics for type 2 diabetes.},
  author={Yun Jung Choi and Dongyun Shin and Ju-Yeun Lee},
  journal={Archives of pharmacal research},
  year={2014},
  volume={37 4},
  pages={435-9}
}
With growing needs for new antidiabetic drugs which are safe and effective alone or in combination with existing drugs, G-protein coupled receptor 40 (GPR40) has drawn a considerable attention as a potential therapeutic target for type 2 diabetes. As GPR40 agonist may offer advantages to commonly used agents, by acting ambient glucose dependent manner which mechanistically leads to reduced risk of developing hypoglycemia. Since deorphanization in 2003, development of small molecule GPR40… CONTINUE READING
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