G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane.

@article{Funakoshi2006GPR,
  title={G protein-coupled receptor 30 is an estrogen receptor in the plasma membrane.},
  author={Takeshi Funakoshi and Akie Yanai and Koh Shinoda and Michio M. Kawano and Yoichi Mizukami},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={346 3},
  pages={904-10}
}
Recently, GPR30 was reported to be a novel estrogen receptor; however, its intracellular localization has remained controversial. To investigate the intracellular localization of GPR30 in vivo, we produced four kinds of polyclonal antibodies for distinct epitopes on GPR30. Immunocytochemical observations using anti-GPR30 antibody and anti-FLAG antibody show that FLAG-GPR30 localizes to the plasma membrane 24 h after transfection. Treatment with estrogen (17beta-estradiol or E2) causes an… CONTINUE READING

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