G protein-coupled receptor 30 contributes to improved remyelination after cuprizone-induced demyelination.

@article{Hirahara2013GPR,
  title={G protein-coupled receptor 30 contributes to improved remyelination after cuprizone-induced demyelination.},
  author={Yukie Hirahara and Ken Matsuda and Hisao Yamada and Akira Saitou and Shinsuke Morisaki and Keiko Takanami and Joan M. Boggs and Mitsuhiro Kawata},
  journal={Glia},
  year={2013},
  volume={61 3},
  pages={420-31}
}
Estrogen exerts neuroprotective and promyelinating actions. The therapeutic effect has been shown in animal models of multiple sclerosis, in which the myelin sheath is specifically destroyed in the central nervous system. However, it remains unproven whether estrogen is directly involved in remyelination via the myelin producing cells, oligodendrocytes, or which estrogen receptors are involved. In this study, we found that the membrane-associated estrogen receptor, the G protein-coupled… CONTINUE READING
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