G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the-catenin pathway

@inproceedings{Yang2005GPL,
  title={G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the-catenin pathway},
  author={Ming Yang and Wendy W. H. Zhong and Neelam Srivastava and Anthony Slavin and Jianxin Yang and Timothy C Hoey and Songzhu Michael An},
  year={2005}
}
Recent studies suggest that lysophosphatidic acid (LPA) and its G protein-coupled receptors (GPCRs) LPA1, LPA2, or LPA3 may play a role in the development of several types of cancers, including colorectal cancer. However, the specific receptor subtype(s) and their signal-transduction pathways responsible for LPA-induced cancer cell proliferation have not been fully elucidated. We show by specific RNA interference (RNAi) that LPA2 and LPA3 but not LPA1 are targets for LPA-induced proliferation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2017

G Protein-Coupled Receptors in Cancer

International journal of molecular sciences • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…