G-protein control of voltage dependence as well as gating of muscarinic metabotropic channels in guinea-pig ileum.

@article{Zholos1994GproteinCO,
  title={G-protein control of voltage dependence as well as gating of muscarinic metabotropic channels in guinea-pig ileum.},
  author={Alexander V. Zholos and Tom B Bolton},
  journal={The Journal of physiology},
  year={1994},
  volume={478 ( Pt 2)},
  pages={195-202}
}
1. Voltage-dependent properties of muscarinic receptor cationic current activated by carbachol in single smooth muscle cells have been studied using patch-clamp recording techniques. Cells were obtained by enzymic digestion from the longitudinal muscle layer of guinea-pig small intestine. 2. The inward cationic current showed a pronounced U-shaped current-voltage relationship (inward current negative). The relationship of cationic conductance to voltage could be described by a Boltzman… CONTINUE READING

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