G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells.

@article{Montoya2007GPB,
  title={G protein betagamma subunits interact with alphabeta- and gamma-tubulin and play a role in microtubule assembly in PC12 cells.},
  author={Valentina Montoya and Christina Marie Gutierrez and Omar Najera and Denisse Leony and Armando Varela-Ram{\'i}rez and Juliana S. Popova and Mark M. Rasenick and Siddhartha Das and Sukla Roychowdhury},
  journal={Cell motility and the cytoskeleton},
  year={2007},
  volume={64 12},
  pages={936-50}
}
The betagamma subunit of G proteins (Gbetagamma) is known to transfer signals from cell surface receptors to intracellular effector molecules. Recent results suggest that Gbetagamma also interacts with microtubules and is involved in the regulation of the mitotic spindle. In the current study, the anti-microtubular drug nocodazole was employed to investigate the mechanism by which Gbetagamma interacts with tubulin and its possible implications in microtubule assembly in cultured PC12 cells… CONTINUE READING