G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.

@article{Sachdev2007GPB,
  title={G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth.},
  author={Pallavi Sachdev and Santosh T Menon and David B. Kastner and J. Z. Chuang and Ting-Yu Yeh and Cecilia B. Conde and Alfredo C{\'a}ceres and C L Sung and Thomas P. Sakmar},
  journal={The EMBO journal},
  year={2007},
  volume={26 11},
  pages={2621-32}
}
Tctex-1, a light-chain component of the cytoplasmic dynein motor complex, can function independently of dynein to regulate multiple steps in neuronal development. However, how dynein-associated and dynein-free pools of Tctex-1 are maintained in the cell is not known. Tctex-1 was recently identified as a Gbetagamma-binding protein and shown to be identical to the receptor-independent activator of G protein signaling AGS2. We propose a novel role for the interaction of Gbetagamma with Tctex-1 in… CONTINUE READING

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