G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone.

@article{Charalampopoulos2006GPS,
  title={G protein-associated, specific membrane binding sites mediate the neuroprotective effect of dehydroepiandrosterone.},
  author={Ioannis Charalampopoulos and Vassilia-Ismini Alexaki and Iakovos Lazaridis and Erene Dermitzaki and Nicolaos Avlonitis and Christos Tsatsanis and Theodora Calogeropoulou and Andrew N. Margioris and Elias Castanas and Achilleas Gravanis},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 3},
  pages={577-9}
}
The neurosteroid dehydroepiandrosterone (DHEA) at 1 nM protects NMDA-/GABAA-receptor negative neural crest-derived PC12 cells from apoptosis. We now report that membrane-impermeable DHEA-BSA conjugate replaces unconjugated DHEA in protecting serum-deprived PC12 cells from apoptosis (IC50=1.5 nM). Protection involves phosphorylation of the prosurvival factor… CONTINUE READING