G-protein antisense oligodeoxyribonucleotides and mu-opioid supraspinal antinociception.

  title={G-protein antisense oligodeoxyribonucleotides and mu-opioid supraspinal antinociception.},
  author={Robert B Raffa and Rebecca P Martinez and Caroline Connelly},
  journal={European journal of pharmacology},
  volume={258 1-2},
The present study utilized an in vivo antisense strategy to examine the functional interaction of supraspinal mu-opioid receptors with the G protein subunits Gi1 alpha, Gi2 alpha, Gi3 alpha and Gs alpha. Mice were injected intracerebroventricularly (i.c.v.) with 33-base phosphorothioate oligodeoxyribonucleotides (12.5 micrograms) or with vehicle in equal volume (sterile water, 5 microliters) and the antinociceptive responses to i.c.v. morphine [D-Ala2,NMePhe4,Gly5-ol]enkephalin (DAMGO) or… CONTINUE READING
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