G protein activation inhibits gating charge movement in rat sympathetic neurons.

@article{HernndezOchoa2007GPA,
  title={G protein activation inhibits gating charge movement in rat sympathetic neurons.},
  author={Erick O Hern{\'a}ndez-Ochoa and Rafael E. Garc{\'i}a-Ferreiro and David E Garcia},
  journal={American journal of physiology. Cell physiology},
  year={2007},
  volume={292 6},
  pages={C2226-38}
}
G protein-coupled receptors (GPCRs) control neuronal functions via ion channel modulation. For voltage-gated ion channels, gating charge movement precedes and underlies channel opening. Therefore, we sought to investigate the effects of G protein activation on gating charge movement. Nonlinear capacitive currents were recorded using the whole cell patch-clamp technique in cultured rat sympathetic neurons. Our results show that gating charge movement depends on voltage with average Boltzmann… CONTINUE READING

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