G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants.

@article{Takahashi2006GPI,
  title={G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants.},
  author={Takehiro Takahashi and Toru Kobayashi and Miwako Ozaki and Yukio Takamatsu and Yasukazu Ogai and Mitsuaki Ohta and Hideko Yamamoto and Kazutaka Ikeda},
  journal={Neuroscience research},
  year={2006},
  volume={54 2},
  pages={104-11}
}
Antidepressants, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), have been widely used for the treatment of not only depression but also other psychiatric disorders, although the molecular mechanisms of the drug effects have not yet been sufficiently revealed. Here, we investigated the in vivo effects of these antidepressants on G protein-activated inwardly rectifying K+ (GIRK) channels, which are important for regulating the excitability of… CONTINUE READING