G-protein αolf subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells

@article{Rgnauld2002GproteinS,
  title={G-protein αolf subunit promotes cellular invasion, survival, and neuroendocrine differentiation in digestive and urogenital epithelial cells},
  author={Karine L R{\'e}gnauld and Quang-De Nguyen and Luc A M-L Vakaet and Erik A. Bruyneel and J. -F. Launay and Takeshi Endo and Marc Mareel and Christian P Gespach and Shahin Emami},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={4020-4031}
}
The heterotrimeric G-protein subunits Gα and Gβγ are involved in cellular transformation and tumor development. Here, we report the expression of Gαolf in human digestive and urogenital epithelial cells using RT–PCR and Western blot. When the constitutively activated form of GαolfQ214L (AGαolf) was stably transfected in canine kidney MDCKts.src and human colonic HCT-8/S11 epithelial cells, it induced cellular invasion in collagen gels. AGαolf-mediated invasion was abrogated by agonists of… CONTINUE READING