G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

@article{Pasternack2008GPR,
  title={G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth},
  author={S. Pasternack and I. K{\"u}gelgen and K. Aboud and Young‐Ae Lee and F. R{\"u}schendorf and K. Voss and A. Hillmer and G. Molderings and T. Franz and A. Ramirez and P. N{\"u}rnberg and M. N{\"o}then and R. Betz},
  journal={Nature Genetics},
  year={2008},
  volume={40},
  pages={329-334}
}
Hypotrichosis simplex is a group of nonsyndromic human alopecias. We mapped an autosomal recessive form of this disorder to chromosome 13q14.11–13q21.33, and identified homozygous truncating mutations in P2RY5, which encodes an orphan G protein–coupled receptor. Furthermore, we identified oleoyl-L-α-lysophosphatidic acid (LPA), a bioactive lipid, as a ligand for P2Y5 in reporter gene and radioligand binding experiments. Homology and studies of signaling transduction pathways suggest that P2Y5… Expand
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