G protein‐coupled receptors: a count of 1001 conformations

  title={G protein‐coupled receptors: a count of 1001 conformations},
  author={G. Vauquelin and I. Van Liefde},
  journal={Fundamental & Clinical Pharmacology},
  • G. Vauquelin, I. Van Liefde
  • Published 2005
  • Biology, Medicine
  • Fundamental & Clinical Pharmacology
  • G protein‐coupled receptors (GPCRs) were initially regarded to adopt an inactive and an active conformation and to activate a single type of G protein. Studies with recombinant cell systems have led to a more complex picture. First, GPCRs can activate distinct G protein species. Second, GPCR multistate models have been invoked to explain their complex behaviour in the presence of agonists, antagonists and other binding partners. The occurrence of intermediate receptor conformational states… CONTINUE READING
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