G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways.

@article{Hooley1996GA1,
  title={G alpha 13 stimulates Na+-H+ exchange through distinct Cdc42-dependent and RhoA-dependent pathways.},
  author={Richard J. Hooley and Chye Yun Yu and Mitchell Symons and Diane L. Barber},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 11},
  pages={
          6152-8
        }
}
Activity of the ubiquitously expressed Na+-H+ exchanger subtype NHE1 is stimulated upon activation of receptor tyrosine kinases and G protein-coupled receptors. The intracellular signaling pathways mediating receptor regulation of the exchanger, however, are poorly understood. Using transient expression of dominant interfering and constitutively active alleles in CCL39 fibroblasts, we determined that the GTPases Ha-Ras and Galpha 13 stimulate NHE1 through distinct signaling cascades. Exchange… CONTINUE READING

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