G-Quadruplex DNA as a target for drug design.

@article{Kerwin2000GQuadruplexDA,
  title={G-Quadruplex DNA as a target for drug design.},
  author={Sean M. Kerwin},
  journal={Current pharmaceutical design},
  year={2000},
  volume={6 4},
  pages={
          441-78
        }
}
Telomeres are structures on the ends of chromosomes that are required for chromosomal stability. Telomeric DNA contains a single-stranded G-rich DNA overhang, which may adopt a G-quadruplex structure. Telomere shortening has been implicated in cellular senescence. Telomerase is an enzyme which synthesizes the G-rich strand of telomere DNA. Telomerase activity is highly correlated with cancer and may allow cancer cells to escape senescence. Based on these observations, telomerase has been… CONTINUE READING

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