G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos

@article{Zwaal1996GPA,
  title={G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos},
  author={Richard R Zwaal and Julie Ahringer and Henri G.A.M van Luenen and Alice Rushforth and Phil Anderson and Ronald H. A. Plasterk},
  journal={Cell},
  year={1996},
  volume={86},
  pages={619-629}
}
Heterotrimeric G proteins are signal-transducing molecules activated by seven transmembrane domain receptors. In C. elegans, gpb-1 encodes the sole Gbeta subunit; therefore, its inactivation should affect all heterotrimeric G protein signaling. When maternal but no zygotic gpb-1 protein (GPB-1) is present, development proceeds until the first larval stage, but these larvae show little muscle activity and die soon after hatching. When, however, the maternal contribution of GPB-1 is also reduced… CONTINUE READING

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