G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.

@article{Michal2012GPR,
  title={G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression.},
  author={Allison M. Michal and Christopher H. So and Neil Beeharry and Haripriya Shankar and Rouzbeh Mashayekhi and Timothy J. Yen and Jeffrey L. Benovic},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 9},
  pages={6928-40}
}
G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptor function and mediate receptor desensitization, internalization, and signaling. While GRKs also interact with and/or phosphorylate many other proteins and modify their function, relatively little is known about the cellular localization of endogenous GRKs. Here we report that GRK5 co-localizes with γ-tubulin, centrin, and pericentrin in centrosomes. The centrosomal localization of GRK5 is observed… CONTINUE READING

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GRK5 Regulates Cell Cycle Progression

  • D. M. Glover, M. H. Leibowitz, D. A. McLean, H. Parry
  • SU N Y H L T H SC I C T R A T B R O O on M arch…
  • 2012

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