G-Protein b-Subunit Specificity in the Fast Membrane-Delimited Inhibition of Ca Channels


We investigated which subtypes of G-protein b subunits participate in voltage-dependent modulation of N-type calcium channels. Calcium currents were recorded from cultured rat superior cervical ganglion neurons injected intranuclearly with DNA encoding five different G-protein b subunits. Gb1 and Gb2 strongly mimicked the fast voltage-dependent inhibition… (More)


6 Figures and Tables