G-Protein b-Subunit Specificity in the Fast Membrane-Delimited Inhibition of Ca Channels

Abstract

We investigated which subtypes of G-protein b subunits participate in voltage-dependent modulation of N-type calcium channels. Calcium currents were recorded from cultured rat superior cervical ganglion neurons injected intranuclearly with DNA encoding five different G-protein b subunits. Gb1 and Gb2 strongly mimicked the fast voltage-dependent inhibition… (More)

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