G Protein and β-arrestin signaling bias at the ghrelin receptor.

Abstract

The G protein-coupled ghrelin receptor GHSR1a is a potential pharmacological target for treating obesity and addiction because of the critical role ghrelin plays in energy homeostasis and dopamine-dependent reward. GHSR1a enhances growth hormone release, appetite, and dopamine signaling through G(q/11), G(i/o), and G(12/13) as well as β-arrestin-based… (More)
DOI: 10.1074/jbc.M114.581397

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