G-Protein activation mediates prepulse facilitation of Ca2+ channel currents in bovine chromaffin cells

@article{Doupnik1994GProteinAM,
  title={G-Protein activation mediates prepulse facilitation of Ca2+ channel currents in bovine chromaffin cells},
  author={Craig A. Doupnik and Raymund Y. K. Pun},
  journal={The Journal of Membrane Biology},
  year={1994},
  volume={140},
  pages={47-56}
}
The effects of G-protein activation were investigated on tonic, large depolarization-induced Ca2+ channel facilitation in cultured bovine adrenal chromaffin cells. Under whole-cell voltage clamp, activation of G proteins by intracellular dialysis with 200 μM GTP-γS did not significantly affect prepulse facilitation or whole-cell Ba2+ current (I Ba) density. In contrast, inactivation of G proteins by intracellular GDP-βS or pertussis toxin (PTX) pretreatment completely abolished or markedly… CONTINUE READING
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Large depolarization relieves purinergic P 2 Y receptor - induced suppression of voltage - gated calcium currents in adrenal chromaffin cells

  • C. A. Doupnik, R. Y. K. Pun
  • Biophys . J .
  • 1993

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