G Protein-Gated Inhibitory Module of N-Type (CaV2.2) Ca2+ Channels

  title={G Protein-Gated Inhibitory Module of N-Type (CaV2.2) Ca2+ Channels},
  author={Heather L. Agler and Jenafer Evans and Lai Hock Tay and Molly J. Anderson and Henry M Colecraft and David T. Yue},
Voltage-dependent G protein (Gbetagamma) inhibition of N-type (CaV2.2) channels supports presynaptic inhibition and represents a central paradigm of channel modulation. Still controversial are the proposed determinants for such modulation, which reside on the principal alpha1B channel subunit. These include the interdomain I-II loop (I-II), the carboxy tail (CT), and the amino terminus (NT). Here, we probed these determinants and related mechanisms, utilizing compound-state analysis with yeast… CONTINUE READING
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