G Protein-Coupled Receptor Signaling in Stem Cells and Cancer

@inproceedings{Lynch2016GPR,
  title={G Protein-Coupled Receptor Signaling in Stem Cells and Cancer},
  author={Jennifer R. Lynch and Jenny Yingzi Wang},
  booktitle={International journal of molecular sciences},
  year={2016}
}
G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recently reported essential roles for G protein-coupled receptor 84 (GPR84) and G protein subunit Gαq in… CONTINUE READING

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